Cancer Currents: An NCI Cancer Research Blog
A blog featuring news and research updates from the National Cancer Institute. Learn more about Cancer Currents.
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In Mouse Study, KRAS-Targeted Drug Shows Potential against Pancreatic CancerAn experimental drug, MRTX1133, shrank tumors or halted their growth in several mouse models of human pancreatic cancer with KRAS G12D mutations, a new study shows. The models included one that is genetically engineered to closely mimic the human disease.
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A Safer, Better Treatment Option for Some Younger Women with Breast CancerFor younger women with advanced breast cancer, the combination of ribociclib (Kisqali) and hormone therapy was much better at shrinking metastatic tumors than standard chemotherapy treatments, results from an NCI-funded clinical trial show.
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New on NCI’s Websites for December 2022NCI periodically provides updates on new websites and other online content of interest to the cancer community. See selected content that has been added as of December 2022.
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Study Identifies a Potential Cause of Immunotherapy’s Heart-Related Side EffectsIn people with cancer treated with immune checkpoint inhibitors, a rare, but often fatal, side effect is inflammation in the heart, called myocarditis. Researchers have now identified a potential chief cause of this problem: T cells attacking a protein in heart cells called α-myosin.
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Reducing the Cancer Burden: Future Directions for NCI's Cancer Control ResearchTo mark her first year at NCI, Dr. Katrina Goddard lays out her research priorities for the Division of Cancer Control and Population Sciences and outlines key opportunities for reducing the burden of cancer. These future directions and priorities are outlined in the division’s 2022 Overview and Highlights report.
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Can Chemotherapy Drugs Be Designed to Avoid Side Effects?Researchers have modified a chemo drug, once abandoned because it caused serious gut side effects, so that it is only triggered in tumors but not normal tissues. After promising results in mice, the drug, DRP-104, is now being tested in a clinical trial.
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Brentuximab Approved for High-Risk Hodgkin Lymphoma in Children and AdolescentsBased on an NCI-sponsored clinical trial conducted by the Children’s Oncology Group, FDA has approved the drug brentuximab vedotin (Adcetris) in combination with chemotherapy for some children and adolescents with Hodgkin lymphoma.
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Drug Combination Shows Promise for Rhabdomyosarcoma, but Can It Get to Clinical Trials?An NCI study in mice has identified a drug combination that may help treat children with rhabdomyosarcoma. But one of the drugs, ganitumab, is no longer being made. Based on the study's promising results, the NCI researchers who led the study want to test the combination in humans.
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Bariatric Surgery May Reduce the Risk of Some Common CancersA new study suggests that people with obesity who had bariatric surgery had a much lower risk of five common cancers that aren’t related to hormone levels, including lung, colorectal, and esophageal cancer.
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Shorter Course of Radiation Is Effective, Safe for Some with Early-Stage Breast CancerIn a large clinical trial, a condensed course of radiation therapy was as effective and safe as a longer standard course for those with higher-risk early-stage breast cancer who had a lumpectomy. This shorter radiation course makes treatment less of a burden for patients.
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Cancer Screening Guidelines Often Lack Information on Potential Harms, Study FindsIn a review of 33 cancer screening guidelines, researchers have found that many don’t adequately capture the potential harms of cancer screening. Providing information on harms is critical so people can have informed discussions about screening with their health care providers, the researchers noted.
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Study in India Could Make Immunotherapy More Affordable WorldwideA study in India has found that an ultra-low dose of the immunotherapy drug nivolumab (Opdivo) helped people with advanced head and neck cancer live longer. Because the dose is 6% of what’s typically used in the United States and Europe, it is potentially more affordable.
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“Oncometabolite” Neutralizes Immune Cells Near TumorsIn a new study, researchers showed that cancer cells with mutations in the IDH1 gene release large amounts of a metabolite called D-2HG. Once outside of the cells, D-2HG acts like force field by neutralizing nearby immune cells.
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COVID-19 Vaccines Are Safe for People Receiving Cancer Immunotherapy, Study ConfirmsmRNA COVID-19 vaccines did not increase the type, frequency, or severity of immune-related side effects among people taking immune checkpoint inhibitors to treat cancer, a study at Memorial Sloan Kettering Cancer Center found. CDC and other medical groups generally recommend that people with cancer receive an mRNA COVID-19 vaccine.
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Changing the Perception of Early-Phase Cancer Clinical Trials: A Conversation with Dr. Naoko TakebeThe number of participants in modern phase 1 cancer clinical trials whose cancer responded to the treatment or remained stable has increased substantially, while treatment-related deaths remained very low, a new NCI study shows. Dr. Naoko Takebe discusses the findings and the importance of phase 1 trials.
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Preventing Chemo Brain? Study Identifies Potential Approach for Common ProblemCisplatin raises levels of a fat molecule called S1P in areas of the brain responsible for memory and information processing, a new study shows. S1P locks onto a protein on the surface of brain cells called S1PR1. In mice given cisplatin, drugs that block S1PR1 prevented cognitive problems.
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Can Targeted Therapy for KRAS Mutations Double as Part of Immunotherapy?Two research teams have developed a treatment approach that could potentially enable KRAS-targeted drugs—and perhaps other targeted cancer drugs—flag cancer cells for the immune system. In lab studies, the teams paired these targeted drugs with experimental antibody drugs that helped the immune system mount an attack.
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For People with Cancer, Are Steroids the Best Treatment for Breathing Problems?Results from a large NCI-funded clinical trial show that steroids were no more effective than a placebo for treating breathing problems in people with advanced cancer. And people treated with steroids were more likely to have serious side effects.
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Is a Genomic Test Better at Finding Aggressive Prostate Cancer?The Decipher genomic test found high-risk prostate cancer even when conventional tests said the tumors were lower risk. This discrepancy appeared to happen more frequently for African-American men.
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Immunotherapy before Surgery Appears Effective for Some with MelanomaFor melanoma that can be treated with surgery, a few doses of pembrolizumab (Keytruda) beforehand looks to be a good choice. In a clinical trial, people who got the presurgical immunotherapy were much less likely to have their cancer come back than those who only received it after surgery.